Guselkumab is a human IgG1λ monoclonal antibody (mAb) that binds selectively to the interleukin 23 (IL-23) protein with high specificity and affinity. IL-23, a regulatory cytokine, affects the differentiation, expansion and survival of T cell subsets and innate immune cell subsets, which represent sources of effector cytokines, including IL-17A, IL-17F and IL-22 that drive inflammatory disease. Levels of IL-23 are elevated in the skin of patients with plaque psoriasis. In in vitro models, guselkumab was shown to inhibit the bioactivity of IL-23 by blocking its interaction with cell surface IL-23 receptor, disrupting IL-23-mediated signaling, activation and cytokine cascades. Guselkumab exerts clinical effects in plaque psoriasis through blockade of the IL-23 cytokine pathway.

Hedrin solution contains dimeticone, which is used in many pharmaceutical and cosmetic preparations. A 4% concentration has been found to affect the physico-physiological activity of lice. It is less effective in its ovicidal activity and therefore two applications, 7 days apart, are required. It contains no neurotoxic organophosphate insecticides and acts by a physical process that covers the lice and disrupts their ability to manage their water balance so that treated insects fail to excrete surplus water. Its activity is not diminished in insecticide-resistant head lice

Dermatoscope that offers precision optics and the functionality to toggle between polarised and non-polarised illumination. No time-consuming exchange of contact plates is necessary, at the same time contact dermatoscopy with immersion liquids is possible at any point, allowing the examination method to be matched with the respective pigmented skin lesion to obtain the best diagnosis. Comes with a rechargeable battery head and USB and power supply.

Classic dermatoscope with high-resolution images provided by achromatic optical system. Toggle function for switching between polarised and non-polarised illumination mode with LED HQ lights. Glare and reflection free. Capable of digital documentation: using the digital camera lens system, the dermatoscope can be connected to the SLR cameras of major brands without any issues. Desk charger or USB.

Dermatoscope with repositioned LEDHQ elements so the light reaches deeper layers of the skin, giving a vivid, spatial impression of lesions. The colorSHIFT function allows easy adjustment of the colour temperature. The optional stable working ring enables the user to examine and manage a lesion under magnification by maintaining a constant distance between the skin and the dermatoscope without contact.

Small dermatoscope with crystal-clear image using the an achromatic optical system and colour rendering due to LEDHQ quality. Includes polarisation and glare-free, LEDHQ and non-reflective working.

Small dermatoscope with bright LED illumination, non-polarised light only and up to 10 hours operation time.

The world’s first and only hidradenitis suppurativa (HS)-specific dressing retention system, intended for use by people with HS lesions in difficult-to-dress areas of the body, such as the armpit, buttocks and groin. The system is made up of two parts: HidraWear reusable baselayers, which act as a dressing retention aid and HidraWear dressings with SecureLock Technology, which are soft & super absorbent, locking in large amounts of exudate. The system removes the need for the dressings to be adhesively attached to the skin leading to quicker, less painful dressing changes, no leakage and more freedom to move.

An emollient bath additive and soap substitute, with light liquid paraffin 37.8% and isopropyl myristate 13%, that contains no known sensitizers.

Formulation containing sodium pyrrolidone carboxylate 2.5%, a powerful humectant that helps to restore the skin’s natural hydrating properties.