Toleriane Ultra

Delgocitinib is a pan Janus kinase (JAK) inhibitor that targets the activity of all four members of the JAK family of enzymes consisting of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2) in a concentration dependent manner.

Cream with pimecrolimus, a lipophilic anti-inflammatory ascomycin macrolactam derivative and a cell selective inhibitor of the production and release of pro-inflammatory cytokines. Its skin-selective pharmacological profile is different to that of corticosteroids.

A soothing moisturiser to help relieve eyelids that are dry, itchy, red and flaky. It contains just three ingredients: Yellow soft paraffin 80%, liquid paraffin 10%, and wool fat (lanolin) 10%. This emollient can be applied to the eyelid skin as frequently as required and is free from sodium lauryl sulphate (SLS), parabens and perfume.

The formula of Eucerin AtoControl Acute Care Cream is a skin-calming complex based on four key ingredients: Omega-6 Fatty Acids, Decandiol, Licochalcone A and Menthoxypropanediol. Irritated and reddened skin is calmed and soothed, helping to improve mild to moderate flare-ups significantly.

Non-steroidal cream designed to relieve the symptoms and signs of eczema (atopic dermatitis), allergic dermatitis (contact dermatitis) and psoriasis. Contains sodium hyaluronate, vitis vinifera seed extract and shea butter, which, when combined, forms an occlusive barrier; attracts moisture to the skin to help restore the skins natural barrier; and has an antioxidant action to help protect the skin barrier.

The mechanism of action of tacrolimus in atopic dermatitis is not fully understood. Whilethe following have been observed, the clinical significance of these observations in atopicdermatitis is not known. Via its binding to a specific cytoplasmic immunophilin (FKBP12),tacrolimus inhibits calcium-dependent signal transduction pathways in T cells, therebypreventing the transcription and synthesis of IL-2, IL-3, IL-4, IL-5 and other cytokines such asGM-CSF, TNF-α and IFN-γ. In patients with atopic dermatitis, improvement of skin lesionsduring treatment with tacrolimus ointment was associated with reduced Fc receptorexpression on Langerhans cells and a reduction of their hyperstimulatory activity towards Tcells. Tacrolimus ointment does not affect collagen synthesis in humans.